Acriflavine Fluorescence?

[Karissa Tilbury]

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All,

  I have a collaborator who is looking into using acriflavine as a topical
contrast agent for a transdermal microneedle injection study to quantify
the disruption and depth of penetration of the device. Has anyone ever used
this? And if so do you have any tips?

Thanks,

Karissa

--
Karissa Tilbury Ph.D
University of Maine
Assistant Professor of Biomedical Engineering
5737 Jenness Hall, Room 211
Orono, ME 04469

[Michael Giacomelli-2]

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Hi Karissa,

Acriflavine stains DNA similar to acridine orange, but is somewhat less
specific. It is relatively permeable in most tissues, so it will probably
diffuse out from the needle to some extent if that matters.

Mike

On Fri, Apr 30, 2021 at 2:32 PM Karissa Tilbury <[hidden email]>
wrote:

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>
> All,
>
>   I have a collaborator who is looking into using acriflavine as a topical
> contrast agent for a transdermal microneedle injection study to quantify
> the disruption and depth of penetration of the device. Has anyone ever used
> this? And if so do you have any tips?
>
> Thanks,
>
> Karissa
>
> --
> Karissa Tilbury Ph.D
> University of Maine
> Assistant Professor of Biomedical Engineering
> 5737 Jenness Hall, Room 211
> Orono, ME 04469
>