HCS
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Dear All
Hope you are fine and doing well! This question could be a bit out of track, but i want to get into HCS (high content screening) and was kind of getting curious about literature available on net wherein i can get acquainted with the intricacies of the same. Please do help! Thanks Best Regards! Niraj Khurana Windows Live Messenger. Multitasking at its finest. |
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Hello Niraj,
If you do a search for "high content screening" on Amazon/books, you'll get a few hits, including these two: 1. High Content Screening: Science, Techniques and Applications by Steven A. Haney (Hardcover - Jan 18, 2008) Buy new: $125.00 $107.43 2. High Content Screening (Methods in Molecular Biology) by D. Lansing Taylor (Hardcover - Aug 15, 2006) Buy new: $149.00 $118.55 I'm not familiar with the first one, but the second book definitely covers quite a lot. If you search PubMed for { "high content screening" Review }, you'll also get a few hits that may be of interest. Finally, you can browse the web sites of the major players (Cellomics, Compucyte, GE, BD, Molecular Devices, PerkinElmer) and see what they have there. A good overview of the various instruments is "High Content Screening emerging importance of novel reagents/probes and pathway analysis" by Dr John Comley If you Google { "High Content Screening emerging importance of novel reagents/probes and pathway analysis" John Comley } you should be able to find the pdf file of the article Julio. -- Julio Vazquez Fred Hutchinson Cancer Research Center Seattle, WA 98109-1024 On Apr 20, 2009, at 10:47 PM, Niraj Khurana wrote: Dear All |
 
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David Basiji |
Re: HCS ***commercial response***
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I'd just like to add Amnis' name to the list of potential
suppliers. Relative to the other systems that Julio mentioned, ours is
particularly well-suited to assays on non-adherent cell types and/or
blood. Please contact me off-line if you'd like more information.
Regards,
David
David Basiji, Ph.D. From: Confocal Microscopy List [mailto:[hidden email]] On Behalf Of Julio Vazquez Sent: Tuesday, April 21, 2009 9:33 AM To: [hidden email] Subject: Re: HCS If you do a search for "high content screening" on Amazon/books, you'll get
a few hits, including these two:
1. High Content Screening: Science, Techniques and Applications by Steven
A. Haney (Hardcover - Jan 18, 2008)
Buy new: $125.00 $107.43
2. High Content Screening (Methods in Molecular Biology) by D. Lansing
Taylor (Hardcover - Aug 15, 2006)
Buy new: $149.00 $118.55
I'm not familiar with the first one, but the second book definitely covers
quite a lot.
If you search PubMed for { "high content screening" Review }, you'll
also get a few hits that may be of interest.
Finally, you can browse the web sites of the major players (Cellomics,
Compucyte, GE, BD, Molecular Devices, PerkinElmer) and see what they have
there.
A good overview of the various instruments is "High Content Screening
emerging importance of novel reagents/probes and pathway analysis" by Dr
John Comley
If you Google { "High Content Screening emerging importance of
novel reagents/probes and pathway analysis" John Comley } you should be
able to find the pdf file of the article
Julio.
--
Julio Vazquez
Fred Hutchinson Cancer Research Center
Seattle, WA 98109-1024
On Apr 20, 2009, at 10:47 PM, Niraj Khurana wrote: Dear All This email and any attachment may contain information which is private and confidential and is intended for the addressee only. If you have received this email in error, please destroy it and notify the sender by return email. |
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In reply to this post by Julio Vazquez
The earlier suggestions are excellent references but a key question to think about earlier than later is what exactly are you trying to measure? It may seem obvious, but a central aspect of these technologies is to try to attach appropriate statistics to something you see by eye in the microscope image. As much as this statement essentially brings all of cell biology under the umbrella of HCS, the reality in the field can be a quite a bit different. A big pharma drug discovery group may be interested in a toxicity profile of 200,000 potential drug candidates whereas an academic researcher may want to accurately quantify the cell-by-cell behavior of lipid droplets under varying conditions & time points, 5 images at a time. The speed, flexibility, accuracy and costs needed to set up these two scenarios would vary wildly. Along the same lines, it's important to consider how open, flexible or dedicated you need the systems to be over time. As we are all intimately aware, microscopy images for biology tend to be highly variable. All the vendors have analysis packages and "validated" assays. These are great if you perform that exact assay. The challenge comes as you want to do something 10% different than the standard or want to compare results from different systems. It takes a certain amount of knowledge and the right kind of flexible tools to make the required adjustments. Good luck on background the search! Best, Casey Laris Vala Sciences Inc. | Director of Applications Voice: 858.461.6862 | Fax: 888.742.1230 On Apr 21, 2009, at 9:32 AM, Julio Vazquez wrote:
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Hi Niraj, A potential source of information could be members of the Australian
High Content Screening Group. We only formed a month or two ago and are still finalising
our website/wiki. But there are contact details for the members, and info on
what equipment/work they are doing. The site can be found at http://ozhcs.wikidot.com/ Cheers Cam Cameron J. Nowell Office: +61 3 9341 3155 This communication is intended only for the named recipient and may contain information that is confidential, legally privileged or subject to copyright; the Ludwig Institute for Cancer Research Ltd does not waiver any rights if you have received this communication in error. The views expressed in this communication are those of the sender and do not necessarily reflect the views of the Ludwig Institute for Cancer Research Ltd. |
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In reply to this post by Niraj Khurana
Hi
Niraj, At
PerkinElmer we provide a range of High Content Screening solutions. If you are
interested in finding out more about the ways in which our products can be used
by researchers such as yourself then you can view our online application notes (http://las.stg.perkinelmer.com/imaging/appnotes.html)
and research posters (http://las.stg.perkinelmer.com/imaging/scientific_imaging_posters.html)
for our Opera high content screening platform. Our
newest product is the Operetta, which offers a bench-top approach to High Content
Screening and which allows researchers who are new to HCS to use preconfigured
applications and quickly become productive. This can be viewed at: http://las.stg.perkinelmer.com/Imaging/Products/HCS/operetta.htm.
We will be adding Operetta application notes and a new research poster online soon,
but if you think these might be useful then I can email you a copy (after our
official launch at SBS Lille next week). I
hope you find the information you are looking for. Thanks, Sarah Sarah Piper PhD From: Confocal Microscopy
List [mailto:[hidden email]] On Behalf Of Niraj
Khurana Dear All Windows
Live Messenger. Multitasking at its finest. |
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In reply to this post by Niraj Khurana
Hi Niraj,
At PerkinElmer we provide a range of High Content Screening solutions. If
you are interested in finding out more about the ways in which our products
can be used by researchers such as yourself then you can view our online
application notes (http://las.stg.perkinelmer.com/imaging/appnotes.html) and
research posters
(http://las.stg.perkinelmer.com/imaging/scientific_imaging_posters.html) for
our Opera high content screening platform.
Our newest product is the Operetta, which offers a bench-top approach to
High Content Screening and which allows researchers who are new to HCS to
use preconfigured applications and quickly become productive. This can be
viewed at: http://las.stg.perkinelmer.com/Imaging/Products/HCS/operetta.htm.
We will be adding Operetta application notes and a new research poster
online soon, but if you think these might be useful then I can email you a
copy (after our official launch at SBS Lille next week).
I hope you find the information you are looking for.
Thanks,
Sarah
Sarah Piper PhD
Applications Specialist
PerkinElmer
Email : [hidden email]
Telephone: +44(0)2476-692-229
Fax +44(0)2476-690-091
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