Job opening within Genzyme Confocal Group

[Peter Piepenhagen]

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http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal

Genzyme Corporation, ranked as one of the foremost biotechnology companies
in the world, is committed to providing an exceptional environment in
which individuals can excel, and achieve their professional and personal
goals. Genzyme Corporation has been selected by FORTUNE magazine as one of
the "100 Best Companies to Work For in 2006 in the United States”. By
applying for a position with Genzyme, you are taking the first step toward
becoming a part of our dynamic and talented team, and sharing in our
continued success.
Staff Scientist I


The confocal microscopy group within the Genzyme Pathology collaborates
with investigators and other members of the confocal group to design and
implement animal model- and cell culture-based studies utilizing advanced
microscopy techniques as the primary readout. Imaging modalities to be
utilized include human interactive and automated confocal microscopy,
fluorescence correlation spectroscopy, time lapse recording, macroscopy,
widefield fluorescence microscopy and structured illumination. In this
position, development of fluorescence-based assays, custom image analysis
algorithms, and downstream statistical tools will be used to extract
biological information from image datasets. Biological interpretation,
report writing, communication of results to investigators, and quality
control will be critical aspects of the position. The position will
involve mostly team-based work with some opportunity for independent
research. You will interact with diverse groups in the Genzyme Science and
Manufacturing organizations. Imaging/image analysis approaches currently
used within the group include confocal microscopy, fluorescence
correlation spectroscopy, high content analysis, widefield microscopy with
or without structured illumination, brightfield and fluorescence
macroscopy, and development of custom image analysis algorithms using a
variety of software packages.

Basic Qualifications:  PhD in cell biology or the life sciences and a
maximum of 3 years academic or industrial laboratory experience.  Requires
2+ years  cell culture and immunofluorescence/ immunohistochemistry
staining experience.

Preferred Qualifications:  Thorough understanding of the principles of
confocal and widefield fluorescence microscopy, cell biological processes
and basic tissue architecture.   Rigorous experimental design experience
and able to develop and troubleshoot novel fluorescence-based assays.  One
or more years experience using Metamorph, Imaris, and/or Matlab image
analysis software and 1 or more years experience with Visual Basic
programming.   One or more years experience using standard biochemical and
molecular biological techniques such as in situ hybridization, PCR,
agarose gel electrophoresis, standard subcloning and restriction analysis,
preparation of protein extracts from cells and tissues,
immunoprecipitation, SDS-PAGE and Western blot analysis will also be
helpful.  Excellent interpersonal and communication skills required.

Please apply at www.genzyme.com and reference job code 10796