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POST DOCTORALPOSITION DESCRIPTIONInter-individualdifferencesinpredispositionandseverityofpulmonaryinfectionsandinflammatorylungdiseasearepoorlyunderstood.SurfactantproteinA(SP-A),asidefromitssurfactant-related functions(i.e.,surfactantstability andstructure,andsurfactantsecretion),hasanessentialroleininnatehostdefense.SP-AmodulatesthephenotypeofalveolarmacrophagesAM,thesentinelcellsoflunginnateimmunity,andenhancesphagocytosisofpathogens, as well as affectscytokine productionandotherhostdefensefunctions.HumanSP-Aisencodedbytwosimilargenes,SP-A1andSP-A2,withspliceandsequencevariantsidentifiedforeach.Theresearchfocusis:a)onthedifferentialregulationofSP-Ageneticvariantsexpressionwithemphasisontheroleof5’UTRand3’UTRontranslation(Noutsios,AJP Lung 2013, 304: L722-L735; Silveyra,AJP
Lung2010,299:L523-L534);b)onmechanismsviawhichSP-Ageneticvariantsdifferentiallymodulatetheexpressionprofileandfunctionofthealveolarmacrophage(Phelps,JofProteomicsandGenomicsRes2013,1(2):2-26;Phelps,Proteome Science 2011, 9:67).The successful candidate must have documented expertise in cell imaging, confocal andfluorescencemicroscopy,molecularbiologyandbiochemistrytechniques,andbeabletoworkwith small animals.Astrong trackrecord ofpublications in peer-reviewed journalsisnecessary.In additionthe candidate
isexpected tobe hard-working,enthusiastic, workindependently,haveexcellentcommandofthe English language,andbe able tointeract
and workwell with others.Pleasee-mailyourCVtoDr.JoannaFloros,Ph.D.EvanPughProfessorofPediatrics,andObstetricsandGynecology,Director,CHILDResearchintheDepartmentofPediatrics,H085.ThePennsylvaniaStateUniversityCollegeofMedicine500UniversityDrive,P.O.Box850Hershey,PA 17033-0850Tel# 717-531-6972;Fax# 717-531-0215;email:
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