Department of Medical Parasitology, NYU School of Medicine
The following postdoctoral position is immediately available:
Immunobiology of Plasmodium in the liver
The cellular mechanisms that lead to the destruction of the intracellular liver stage of the malaria parasite by the cellular immune response of the host are poorly understood. Considering the unique immune properties of the liver, it is conceivable that the different antigen-presenting cells of the liver fulfill distinct but complementary roles during the effector phase against Plasmodium liver stages. We aim to analyze these events on a cellular basis in real time, both by in live mice and in cultures of purified liver cells in vitro.
The available project will focus on cell biological aspects of the interaction between malaria-specific effector T cells and Plasmodium-infected hepatocytes and various hepatic antigen-presenting cells. Techniques such as maintenance of T cell clones, purification and cultivation of various liver cell types, Plasmodium sporozoite isolation and invasion experiments, cellular cytotoxicity assays, live cell imaging, immunolabeling, confocal and electron microscopy will be involved.
Interested applicants with a strong background in microscopic imaging, cell biology of protozoan parasites, cellular immunology, or immunobiology of the liver may consult a recent review (Frevert & Nardin, Cell Microbiol 10, 2008, 1956) for further information.
Please send a curriculum vitae including a short description of research interests, training and experience, and at least three references by email to:
Ute Frevert, DVM, PhD
Department of Medical Parasitology
NYU School of Medicine
341 E 25 St
New York, NY 10010
Tel 212-263-6755
Email:
[hidden email]
Website:
http://parasitology.med.nyu.edu/people/faculty/ute-frevert/laboratory------------------------------------------------------------
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