Postdoctoral positions

[Frevert-Clarkson, Ute]

Department of Medical Parasitology, NYU School of Medicine

Two postdoctoral positions are immediately available:

1) Imaging Lyme neuroborreliosis
Lyme neuroborreliosis, caused by the spirochete Borrelia burgdorferi, is characterized by widespread dysfunction of the central nervous system. While much is known about the role of ticks in the transmission of B. burgdorferi, the biology of this pathogenic agent in various mammalian hosts, and the multi-organ involvement of the disease caused by this spirochete, little information is available on the dynamics of Borrelia interaction with the brain and the pathogenesis of neuroborreliosis.
The available project will focus on the interaction of Borrelia as well as cells of the innate immune system with the cerebral microvasculature. Techniques such as Borrelia cultivation, infection of small animals, intravital microscopy and live cell imaging, tissue preservation and immunolabeling, confocal and electron microscopy will be involved.
Interested applicants with a strong background in borreliosis, neuroscience, immunobiology of the brain, intravital imaging, cell biology, or infectious diseases please send a curriculum vitae including a short description of research interests, training and experience, and at least three references by email.

2) Immunobiology of Plasmodium in the liver
Little is known about the cellular interactions that occur in vivo, when the intracellular hepatic stage of the malaria parasite is targeted by the cellular immune response and eventually destroyed. Considering the unique immune properties of the liver, it is conceivable that the different antigen-presenting cells of the liver fulfill distinct but complementary roles during the effector phase against Plasmodium liver stages.
The available project will focus on cell biological aspects of the interaction between malaria-specific effector T cells and Plasmodium-infected hepatocytes as well as hepatic antigen-presenting cells. Techniques such as maintenance of T cell clones, purification and cultivation of various liver cell types, Plasmodium sporozoite isolation and invasion experiments, cellular cytotoxicity assays, live cell imaging, immunolabeling, confocal and electron microscopy will be involved.
Interested applicants with a strong background in microscopic imaging, cell biology of protozoan parasites, cellular immunology, or immunobiology of the liver may consult a recent review (Frevert & Nardin, Cell Microbiol 10, 2008, 1956) for further information. Please send a curriculum vitae including a short description of research interests, training and experience, and at least three references by email to:

Ute Frevert, DVM, PhD
Department of Medical Parasitology
NYU School of Medicine
341 E 25 St
New York, NY 10010
Tel [phone]
Email: Ute.Frevert@...
Website: http://parasitology.med.nyu.edu/people/faculty/ute-frevert/laboratory

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