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Dear,
regarding my previous email, one of the approaches I would like to develop is related to an approach that different groups had between late 80s and the 90s starting from an idea by Norman, Maestre, Tinoco Jr. and Bustamante and some others about the understanding of the signal in the tails of CD signature of macromolecules outside their absorption bands. For sake of simplicity I will use the acronym of CIDS (Circular Intensity Differential Scattering) for the element S14 of the Mueller matrix when referring to the artifacts in the CD tails outside the absorption bands.
I was fascinated by CIDS and I am still fascinated: a label free and scattering based approach. I was young, I started and for some reasons - as others (Bustamante had a great series of papers on Biophysical Journal about the charming possibility of using “ CIDS" for Microscopy Imaging with Laura Finzi and others) - I stopped. Today, I think that I can start again integrating such approach with nanoscopia and single molecule imaging. This allows to pose new questions about Chromatin-DNA and its role in cell functioning. My main interest is again on the role of high-order organization of chromatin-DNA.
Sorry for discontinuities in the narration or some confusion. Happy to discuss about it.
The link to the paper on CIDS that for sure had and has several limitations is the following:
Best
Alby
Subject: Chromatin-DNA ARP
Alberto
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