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Dear Confocal listserv members,
if you are into fluorescent protein biosensors, I encourage checking out
GE's sensors for bioreactors challenge
https://www.linkedin.com/pulse/ge-innovation-challenge-sensors-small-biological-paul-goodwinhttps://gex.brightidea.com/ct/a.bix?c=EED4F00D-7CBE-47EA-996B-D5C928387C3A*Phase 1 Guidelines*: You should propose a technology that senses and
reports the biological environment analyte shown below either directly
in a bioreactor or remotely outside of it —for which the analysis of
those activities can be used to improve cell therapy process control.
*Analyte*
*Sensitivity Required*
*Sampling Frequency*
Glucose
0-100mM; 0-18g/L
1 measurement per hour
Lactate
0-55mM; 0-9 g/L
1 measurement per hour
Glutamine
0-10mM; 0-1.5g/L
1 measurement per hour
Glutamate
0-14mM; 0-2g/L
1 measurement per hour
Proteins
nM-pM
12-24 measurements per day
Cell epitopes
nM-pM
3-6 measurements per day
As i note in my comment to Paul's Pulse blog, 4 small molecules is a
small number. I've previously posted online how to extend the dynamic
range for any analyte that has an affinity series of FP biosensors,
http://home.earthlink.net/~pubspectra/McNamara_20121023Tue_Tattletales_GFP_Public_Domain.jpg
Sincerely,
George
--
George McNamara, PhD
Houston, TX 77054
[hidden email]
https://www.linkedin.com/in/georgemcnamarahttps://works.bepress.com/gmcnamara/75/http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/44962650
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