*****
To join, leave or search the confocal microscopy listserv, go to:
http://lists.umn.edu/cgi-bin/wa?A0=confocalmicroscopyPost images on
http://www.imgur.com and include the link in your posting.
*****
The Lab of Edgar Gomes (
https://imm.medicina.ulisboa.pt/en/investigacao/labs/gomes-lab/)
is looking for talented and curious post-docs to join our lab at the Institute of Molecular
Medicine (IMM), Lisbon, Portugal, under the support of an ERC consolidator grant (PhoNICs -
Positioning the nucleus for cell migration and muscle fiber function) and EMBO installation
grant.
We want to identify new mechanisms that regulate and drive the position of the nucleus inside
cells, how the cytoskeleton is connected with the nuclear envelope, how this connection is
regulated and what is the role for nuclear positioning in cellular functions. Our favorite models
are mouse migrating cells (2D and 3D) and skeletal muscle and we use multiple biochemistry,
in-silico modeling, cell biology, high- and super-resolution microscopy approaches to address
these questions.
Candidates should have a Master or a PhD degree, fertile imagination and passionate curiosity
to understand mechanistic processes. Experience in cloning, protein biochemistry,
immunofluorescence and time-lapse microscopy is preferred.
References:
Sestina Falcone, William Roman, Karim Hnia, Vincent Gache, Nathalie Didier, Jeanne Lainé,
Frederic Aurade, Isabelle Marty, Ichizo Nishino, Nicolas Charlet-Berguerand, Norma Romero,
Giovanna Marazzi, David Sassoon, Jocelyn Laporte, Edgar R. Gomes. N-WASP is required for
Amphiphysin-2/BIN1 dependent nuclear positioning and triad organization in skeletal muscle
and is involved in the pathophysiology of centronuclear myopathy. EMBO Mol Med 6, 1455–
1475 (2014)
Metzger, T., Gache, V., Xu, M., Cadot, B., Folker, E., Richardson, B., Gomes, E.R.*, Baylies,
M.K.*. MAP and Kinesin dependent nuclear positioning is required for skeletal muscle function.
Nature 484, 120–124 (2012), *co-last and corresponding author
Borrego-Pinto, J., Jegou, T., Osorio, D., Aurade, F., Gorjánácz, M., Koch, B., Mattaj, I., and
Gomes, E. R. (2011). Samp1 is a new component of the TAN lines and is required for nuclear
movement. Journal of Cell Science, 125, 1099–105 (2012)
Applications (CV and cover letter) should be sent to
[hidden email] until
15th of March.
Locked
