Re: Usefulness of super-resolution?

Posted by Jakub Chojnacki on
URL: http://confocal-microscopy-list.275.s1.nabble.com/Usefulness-of-super-resolution-tp7587169p7587170.html

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Dear Gabor,

I realise that I am promoting my own work here, but here is a clear example
of a discovery of the novel mechanism important for HIV entry competence.
This work would not be possible without a super-resolution microscopy
approach (in this case STED).
http://science.sciencemag.org/content/338/6106/524

Hope this helps.

Regards,
Jakub

On 19 August 2017 at 16:46, Csúcs Gábor <[hidden email]> wrote:

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>
>
> Dear All,
>
> I would have a slightly provocative question to the community: Could you
> help me to identify significant/major biological discoveries that were
> clearly dependent on the availability of various super-resolution light
> microscopy methods? The PNAS paper from the Zhuang lab (2016) about the
> actin-spectrin ring is a good example for me but I am looking for further
> ones. Of course, we also use super-resolution techniques in our facility
> but my observation is that these are used rather to provide "one nice image
> for a publication" or "another piece in the puzzle of evidences" but they
> are not "game winners", they were not necessarily the major piece of
> evidence to prove a biological hypothesis. So I am looking for biological
> questions that could be answered "only"/mostly by the existing
> super-resolution methods.
>         Thanks a lot for your help!
>
> Greetings                       Gabor
>
>