First commercial single point confocal
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Zarda, Boris |
First commercial single point confocal
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Search the CONFOCAL archive at
http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal Dear all, one of my customers asked me the question about what was the first commercial single point scanner. I was much tempted to answer straight away with "Biorad", but the longer I think about it the more I am in doubt. At that time I was in my (microscopic) larvae stage and I am not sure to have the time scale right. And I would like to give the correct answer unbiased by company or geographic issues. Your input would be much appreciated Boris ___________________________________________________ Boris Zarda Dr. rer. nat. Sales Manager Research Switzerland Leica Microsystems (Schweiz) AG Verkaufsgesellschaft Max Schmidheiny-Strasse 201 CH-9435 Heerbrugg Tel +41 44 768 36 30 Fax +41 71 726 34 44 ______________________________________________________________________ This email has been scanned by the MessageLabs Email Security System. For more information please visit http://www.messagelabs.com/email ______________________________________________________________________ |
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Search the CONFOCAL archive at
http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal I'm sure you are right about the Bio-Rad in principle, but it wasn't the well-known MRC 500, but the very different SOM 100. In fact so far as I can find out the first microscope advertised for sale was by Oxford Optoelectronics but I believe that before the first one was delivered the design had been taken over by a company called Dubilier, who were thus the first to actually sell one. Dubilier was then bought by Polaron who in turn were taken over by Bio-Rad. The SOM 100 was a stage-scanning machine using a He-Ne laser and was intended for reflection imaging, so it found little use in biology. Bio-Rad soon dumped it in favour of Brad Amos' MRC design, which had biological imaging as its first priority. This caused some grief to the Oxford team who had developed the SOM - and just to rub salt into the wound it was a design from Cambridge which supplanted it! Guy Optical Imaging Techniques in Cell Biology by Guy Cox CRC Press / Taylor & Francis http://www.guycox.com/optical.htm ______________________________________________ Associate Professor Guy Cox, MA, DPhil(Oxon) Electron Microscope Unit, Madsen Building F09, University of Sydney, NSW 2006 ______________________________________________ Phone +61 2 9351 3176 Fax +61 2 9351 7682 Mobile 0413 281 861 ______________________________________________ http://www.guycox.net -----Original Message----- From: Confocal Microscopy List [mailto:[hidden email]] On Behalf Of Boris Zarda Sent: Monday, 5 November 2007 8:03 PM To: [hidden email] Subject: First commercial single point confocal Search the CONFOCAL archive at http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal Dear all, one of my customers asked me the question about what was the first commercial single point scanner. I was much tempted to answer straight away with "Biorad", but the longer I think about it the more I am in doubt. At that time I was in my (microscopic) larvae stage and I am not sure to have the time scale right. And I would like to give the correct answer unbiased by company or geographic issues. Your input would be much appreciated Boris ___________________________________________________ Boris Zarda Dr. rer. nat. Sales Manager Research Switzerland Leica Microsystems (Schweiz) AG Verkaufsgesellschaft Max Schmidheiny-Strasse 201 CH-9435 Heerbrugg Tel +41 44 768 36 30 Fax +41 71 726 34 44 ______________________________________________________________________ This email has been scanned by the MessageLabs Email Security System. For more information please visit http://www.messagelabs.com/email ______________________________________________________________________ No virus found in this incoming message. Checked by AVG Free Edition. Version: 7.5.503 / Virus Database: 269.15.21/1110 - Release Date: 4/11/2007 9:37 PM No virus found in this outgoing message. Checked by AVG Free Edition. Version: 7.5.503 / Virus Database: 269.15.22/1112 - Release Date: 5/11/2007 7:11 PM |
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Michael Cammer |
Re: First commercial single point confocal
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In reply to this post by Zarda, Boris
Search the CONFOCAL archive at
http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal What was the vintage of the Sarastro(sp?)? Or is this the SOM 100. At least now I have an idea where the name of the SOM software we used on the BioRad came from. Thanks! -mc > Search the CONFOCAL archive at > http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal > > I'm sure you are right about the Bio-Rad in > principle, but it wasn't the well-known MRC > 500, but the very different SOM 100. In fact > so far as I can find out the first microscope > advertised for sale was by Oxford Optoelectronics > but I believe that before the first one was > delivered the design had been taken over by a company > called Dubilier, who were thus the first to actually > sell one. Dubilier was then bought by Polaron > who in turn were taken over by Bio-Rad. > > The SOM 100 was a stage-scanning machine using a > He-Ne laser and was intended for reflection imaging, > so it found little use in biology. Bio-Rad soon > dumped it in favour of Brad Amos' MRC design, which > had biological imaging as its first priority. This > caused some grief to the Oxford team who had developed > the SOM - and just to rub salt into the wound it was > a design from Cambridge which supplanted it! > > Guy > > Optical Imaging Techniques in Cell Biology > by Guy Cox CRC Press / Taylor & Francis > http://www.guycox.com/optical.htm > ______________________________________________ > Associate Professor Guy Cox, MA, DPhil(Oxon) > Electron Microscope Unit, Madsen Building F09, > University of Sydney, NSW 2006 > ______________________________________________ > Phone +61 2 9351 3176 Fax +61 2 9351 7682 > Mobile 0413 281 861 > ______________________________________________ > http://www.guycox.net > -----Original Message----- > From: Confocal Microscopy List [mailto:[hidden email]] On > Behalf Of Boris Zarda > Sent: Monday, 5 November 2007 8:03 PM > To: [hidden email] > Subject: First commercial single point confocal > > Search the CONFOCAL archive at > http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal > > Dear all, > > one of my customers asked me the question about what was the first > commercial single point scanner. I was much tempted to answer straight > away with "Biorad", but the longer I think about it the more I am in > doubt. At that time I was in my (microscopic) larvae stage and I am not > sure to have the time scale right. And I would like to give the correct > answer unbiased by company or geographic issues. > > Your input would be much appreciated > > Boris > ___________________________________________________ > > Boris Zarda > Dr. rer. nat. > Sales Manager Research Switzerland > > Leica Microsystems (Schweiz) AG > Verkaufsgesellschaft > Max Schmidheiny-Strasse 201 > CH-9435 Heerbrugg > Tel +41 44 768 36 30 > Fax +41 71 726 34 44 > > > > ______________________________________________________________________ > This email has been scanned by the MessageLabs Email Security System. > For more information please visit http://www.messagelabs.com/email > ______________________________________________________________________ > > No virus found in this incoming message. > Checked by AVG Free Edition. > Version: 7.5.503 / Virus Database: 269.15.21/1110 - Release Date: > 4/11/2007 9:37 PM > > > No virus found in this outgoing message. > Checked by AVG Free Edition. > Version: 7.5.503 / Virus Database: 269.15.22/1112 - Release Date: > 5/11/2007 7:11 PM > > _________________________________________ Michael Cammer http://www.aecom.yu.edu/aif/ |
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In reply to this post by Zarda, Boris
Search the CONFOCAL archive at
http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal I have in front of me an advert for the SOM 100 Lasersharp from Bio-Rad (Polaron Division). Some names persisted a long time! This was early 1987 - the MRC 500 was launched later that year. This was the Oxford design from Colin Sheppard and Tony Wilson, which had been on the market on a small scale for a few years before that. Both Sarastro (Kjell Carlsson's design), later to be Molecular Dynamics, and Heidelberg Instruments (later to become part of Leica) were not far behind. Guy Optical Imaging Techniques in Cell Biology by Guy Cox CRC Press / Taylor & Francis http://www.guycox.com/optical.htm ______________________________________________ Associate Professor Guy Cox, MA, DPhil(Oxon) Electron Microscope Unit, Madsen Building F09, University of Sydney, NSW 2006 ______________________________________________ Phone +61 2 9351 3176 Fax +61 2 9351 7682 Mobile 0413 281 861 ______________________________________________ http://www.guycox.net -----Original Message----- From: Confocal Microscopy List [mailto:[hidden email]] On Behalf Of Michael Cammer Sent: Tuesday, 6 November 2007 1:06 PM To: [hidden email] Subject: Re: First commercial single point confocal Search the CONFOCAL archive at http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal What was the vintage of the Sarastro(sp?)? Or is this the SOM 100. At least now I have an idea where the name of the SOM software we used on the BioRad came from. Thanks! -mc > Search the CONFOCAL archive at > http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal > > I'm sure you are right about the Bio-Rad in principle, but it wasn't > the well-known MRC 500, but the very different SOM 100. In fact so > far as I can find out the first microscope advertised for sale was by > Oxford Optoelectronics but I believe that before the first one was > delivered the design had been taken over by a company called Dubilier, > who were thus the first to actually sell one. Dubilier was then > bought by Polaron who in turn were taken over by Bio-Rad. > > The SOM 100 was a stage-scanning machine using a He-Ne laser and was > intended for reflection imaging, so it found little use in biology. > Bio-Rad soon dumped it in favour of Brad Amos' MRC design, which had > biological imaging as its first priority. This caused some grief to > the Oxford team who had developed the SOM - and just to rub salt into > the wound it was a design from Cambridge which supplanted it! > > Guy > > Optical Imaging Techniques in Cell Biology > by Guy Cox CRC Press / Taylor & Francis > http://www.guycox.com/optical.htm > ______________________________________________ > Associate Professor Guy Cox, MA, DPhil(Oxon) Electron Microscope Unit, > Madsen Building F09, University of Sydney, NSW 2006 > ______________________________________________ > Phone +61 2 9351 3176 Fax +61 2 9351 7682 > Mobile 0413 281 861 > ______________________________________________ > http://www.guycox.net > -----Original Message----- > From: Confocal Microscopy List [mailto:[hidden email]] > On Behalf Of Boris Zarda > Sent: Monday, 5 November 2007 8:03 PM > To: [hidden email] > Subject: First commercial single point confocal > > Search the CONFOCAL archive at > http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal > > Dear all, > > one of my customers asked me the question about what was the first > commercial single point scanner. I was much tempted to answer straight > away with "Biorad", but the longer I think about it the more I am in > doubt. At that time I was in my (microscopic) larvae stage and I am > not sure to have the time scale right. And I would like to give the > correct answer unbiased by company or geographic issues. > > Your input would be much appreciated > > Boris > ___________________________________________________ > > Boris Zarda > Dr. rer. nat. > Sales Manager Research Switzerland > > Leica Microsystems (Schweiz) AG > Verkaufsgesellschaft > Max Schmidheiny-Strasse 201 > CH-9435 Heerbrugg > Tel +41 44 768 36 30 > Fax +41 71 726 34 44 > > > > ______________________________________________________________________ > This email has been scanned by the MessageLabs Email Security System. > For more information please visit http://www.messagelabs.com/email > ______________________________________________________________________ > > No virus found in this incoming message. > Checked by AVG Free Edition. > Version: 7.5.503 / Virus Database: 269.15.21/1110 - Release Date: > 4/11/2007 9:37 PM > > > No virus found in this outgoing message. > Checked by AVG Free Edition. > Version: 7.5.503 / Virus Database: 269.15.22/1112 - Release Date: > 5/11/2007 7:11 PM > > _________________________________________ Michael Cammer http://www.aecom.yu.edu/aif/ No virus found in this incoming message. Checked by AVG Free Edition. Version: 7.5.503 / Virus Database: 269.15.22/1112 - Release Date: 5/11/2007 7:11 PM No virus found in this outgoing message. Checked by AVG Free Edition. Version: 7.5.503 / Virus Database: 269.15.22/1112 - Release Date: 5/11/2007 7:11 PM |
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Martin Wessendorf |
Re: First commercial single point confocal
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Search the CONFOCAL archive at
http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal Guy et al-- I think that prior to either of these, there was a non-laser scanning instrument featuring a single eyepiece (!) and probably the least ergonomic design of any microscope. It was made by a company in Wisconsin, USA, but unfortunately I can no longer remember the name! However, I do remember that they got the cover of Science in (if I'm correct) 1986 showing a picture of a Golgi-stained cerebellar Purkinje cell. Martin Guy Cox wrote: > Search the CONFOCAL archive at > http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal > > I have in front of me an advert for the > SOM 100 Lasersharp from Bio-Rad (Polaron > Division). Some names persisted a long > time! This was early 1987 - the MRC 500 > was launched later that year. This was > the Oxford design from Colin Sheppard and > Tony Wilson, which had been on the market > on a small scale for a few years before that. > > Both Sarastro (Kjell Carlsson's design), later > to be Molecular Dynamics, and Heidelberg > Instruments (later to become part of Leica) > were not far behind. > > Guy -- Martin Wessendorf, Ph.D. office: (612) 626-0145 Assoc Prof, Dept Neuroscience lab: (612) 624-2991 University of Minnesota Preferred FAX: (612) 624-8118 6-145 Jackson Hall, 321 Church St. SE Dept Fax: (612) 626-5009 Minneapolis, MN 55455 E-mail: martinw[at]med.umn.edu |
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In reply to this post by Zarda, Boris
Search the CONFOCAL archive at
http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal Yes, but that was a spinning-disk system. The query was about point scanners. Mojimir Petran's 'Tandem Scanning Microscope' was made in small numbers by a tractor maker (!) in Czechoslovakia. I believe Alan Boyde was the first customer. It had, as you say, a single vertical eyepiece. Tracor-Northern in Madison (now Thermo Noran, I think) took out a licence and soon added a proper binocular head (not really hard to do). It was supported by their TN 8502 Image Analysis system and you could do some quite neat things with the combination, like taking a stereo pair without needing to acquire an image stack. Mind you, last time I used a modern Perkin Elmer spinning disk system the eyepiece for the direct ocular view was still single and very inconvenient! I guess they don't think people will use it. Guy Optical Imaging Techniques in Cell Biology by Guy Cox CRC Press / Taylor & Francis http://www.guycox.com/optical.htm ______________________________________________ Associate Professor Guy Cox, MA, DPhil(Oxon) Electron Microscope Unit, Madsen Building F09, University of Sydney, NSW 2006 ______________________________________________ Phone +61 2 9351 3176 Fax +61 2 9351 7682 Mobile 0413 281 861 ______________________________________________ http://www.guycox.net -----Original Message----- From: Confocal Microscopy List [mailto:[hidden email]] On Behalf Of Martin Wessendorf Sent: Tuesday, 6 November 2007 5:16 PM To: [hidden email] Subject: Re: First commercial single point confocal Search the CONFOCAL archive at http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal Guy et al-- I think that prior to either of these, there was a non-laser scanning instrument featuring a single eyepiece (!) and probably the least ergonomic design of any microscope. It was made by a company in Wisconsin, USA, but unfortunately I can no longer remember the name! However, I do remember that they got the cover of Science in (if I'm correct) 1986 showing a picture of a Golgi-stained cerebellar Purkinje cell. Martin Guy Cox wrote: > Search the CONFOCAL archive at > http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal > > I have in front of me an advert for the SOM 100 Lasersharp from > Bio-Rad (Polaron Division). Some names persisted a long time! This > was early 1987 - the MRC 500 was launched later that year. This was > the Oxford design from Colin Sheppard and Tony Wilson, which had been > on the market on a small scale for a few years before that. > > Both Sarastro (Kjell Carlsson's design), later to be Molecular > Dynamics, and Heidelberg Instruments (later to become part of Leica) > were not far behind. > > Guy -- Martin Wessendorf, Ph.D. office: (612) 626-0145 Assoc Prof, Dept Neuroscience lab: (612) 624-2991 University of Minnesota Preferred FAX: (612) 624-8118 6-145 Jackson Hall, 321 Church St. SE Dept Fax: (612) 626-5009 Minneapolis, MN 55455 E-mail: martinw[at]med.umn.edu No virus found in this incoming message. Checked by AVG Free Edition. Version: 7.5.503 / Virus Database: 269.15.22/1112 - Release Date: 5/11/2007 7:11 PM No virus found in this outgoing message. Checked by AVG Free Edition. Version: 7.5.503 / Virus Database: 269.15.22/1112 - Release Date: 5/11/2007 7:11 PM |
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Eric Scarfone |
Re: First commercial single point confocal
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In reply to this post by Zarda, Boris
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http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal Hey if one stick to laser (point) scanning I'd say 1)BioRad; 2)Sarastro; 3)Leica in order of appearance. With BioRad being one generation ahead of the others. I actually saw the fisrt prototype of the MRC 500 in Brad Amos's lab who was still using it back in '91. Eric Eric Scarfone, PhD, CNRS, Center for Hearing and communication Research Department of Clinical Neuroscience Karolinska Institutet Postal Address: CFH, M1:02 Karolinska Hospital, SE-171 76 Stockholm, Sweden Work: +46 (0)8-517 70343, Cell: +46 (0)70 888 2352 Fax: +46 (0)8-301876 email: [hidden email] http://www.ki.se/cfh/ ----- Original Message ----- From: Boris Zarda <[hidden email]> Date: Monday, November 5, 2007 8:31 pm Subject: First commercial single point confocal To: [hidden email] > Search the CONFOCAL archive at > http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal > > Dear all, > > one of my customers asked me the question about what was the first > commercial single point scanner. I was much tempted to answer > straight away > with "Biorad", but the longer I think about it the more I am in > doubt. At > that time I was in my (microscopic) larvae stage and I am not sure > to have > the time scale right. And I would like to give the correct answer > unbiasedby company or geographic issues. > > Your input would be much appreciated > > Boris > ___________________________________________________ > > Boris Zarda > Dr. rer. nat. > Sales Manager Research Switzerland > > Leica Microsystems (Schweiz) AG > Verkaufsgesellschaft > Max Schmidheiny-Strasse 201 > CH-9435 Heerbrugg > Tel +41 44 768 36 30 > Fax +41 71 726 34 44 > > > > ______________________________________________________________________ > This email has been scanned by the MessageLabs Email Security System. > For more information please visit http://www.messagelabs.com/email > ______________________________________________________________________ > |
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Barbara Foster |
Re: First commercial single point confocal
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In reply to this post by Martin Wessendorf
Search the CONFOCAL archive at
http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal
Hi, Martin
Was that Meridian? If so, it was an interesting instrument because in addition to doing confocal imaging it did laser ablation. They sold a special form of growth medium that was especially sensitive to one of the laser lines. It enabled you to grow cells in culture then either "zap" cells that you did not want to see or to cut out "islands" of cells that you wanted to harvest/view. By the way, the first single point laser scanner I remember is also the SOM. I remember collecting a short file on it while working at Cambridge Instruments around 1986-87. Best regards, Barbara Foster, President We've moved! Microscopy/Microscopy Education 7101 Royal Glen Trail, Suite A McKinney TX 75070 P: (972)924-5310 Skype: fostermme W: www.MicroscopyEducation.com MME is now scheduling customized, on-site courses through December. Call us today for details. P. S. Need a good general reference or light microscopy text for next semester? Call us today to learn more about "Optimizing LIght Microscopy". Copies still available through MME... even for class-room lots ... and we give quantity discounts. Just call us here in the MME office for details. At 08:10 AM 11/6/2007, you wrote: Search the CONFOCAL archive at |
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Nina Allen |
Re: First commercial single point confocal
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In reply to this post by Guy Cox
Search the CONFOCAL archive at
http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal And the Traco-Northern spinning disk gave good images. It had several problems however. One was low intensity so you needed Bright fluorescence. The other was stability ... Nina Allen On 11/6/07 1:30 AM, "Guy Cox" <[hidden email]> wrote: > Search the CONFOCAL archive at > http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal > > Yes, but that was a spinning-disk system. The query > was about point scanners. Mojimir Petran's 'Tandem > Scanning Microscope' was made in small numbers > by a tractor maker (!) in Czechoslovakia. I believe > Alan Boyde was the first customer. It had, as you > say, a single vertical eyepiece. Tracor-Northern in > Madison (now Thermo Noran, I think) took out a licence > and soon added a proper binocular head (not really hard > to do). It was supported by their TN 8502 Image > Analysis system and you could do some quite neat > things with the combination, like taking a stereo pair > without needing to acquire an image stack. > > Mind you, last time I used a modern Perkin Elmer > spinning disk system the eyepiece for the direct > ocular view was still single and very inconvenient! > I guess they don't think people will use it. > > Guy > > > > Optical Imaging Techniques in Cell Biology > by Guy Cox CRC Press / Taylor & Francis > http://www.guycox.com/optical.htm > ______________________________________________ > Associate Professor Guy Cox, MA, DPhil(Oxon) > Electron Microscope Unit, Madsen Building F09, > University of Sydney, NSW 2006 > ______________________________________________ > Phone +61 2 9351 3176 Fax +61 2 9351 7682 > Mobile 0413 281 861 > ______________________________________________ > http://www.guycox.net > -----Original Message----- > From: Confocal Microscopy List [mailto:[hidden email]] On > Behalf Of Martin Wessendorf > Sent: Tuesday, 6 November 2007 5:16 PM > To: [hidden email] > Subject: Re: First commercial single point confocal > > Search the CONFOCAL archive at > http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal > > Guy et al-- > > I think that prior to either of these, there was a non-laser scanning > instrument featuring a single eyepiece (!) and probably the least ergonomic > design of any microscope. It was made by a company in Wisconsin, USA, but > unfortunately I can no longer remember the name! > However, I do remember that they got the cover of Science in (if I'm > correct) 1986 showing a picture of a Golgi-stained cerebellar Purkinje cell. > > Martin > > Guy Cox wrote: >> Search the CONFOCAL archive at >> http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal >> >> I have in front of me an advert for the SOM 100 Lasersharp from >> Bio-Rad (Polaron Division). Some names persisted a long time! This >> was early 1987 - the MRC 500 was launched later that year. This was >> the Oxford design from Colin Sheppard and Tony Wilson, which had been >> on the market on a small scale for a few years before that. >> >> Both Sarastro (Kjell Carlsson's design), later to be Molecular >> Dynamics, and Heidelberg Instruments (later to become part of Leica) >> were not far behind. >> >> Guy Nina Stromgren Allen Professor of Plant Biology Director, Cellular and Molecular Imaging Facility Past Chair of the Faculty Department of Plant Biology Box 7612 North Carolina State University Raleigh, North Carolina 27695-7612 Phone: 919-515-8382, 3525 Fax: 919-515-3436 |
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Wiegraebe, Winfried |
Re: First commercial single point confocal
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In reply to this post by Zarda, Boris
Search the CONFOCAL archive at
http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal
How do the Zeiss laser scanning and confocal microscopes fit into this history?
Winfried --------------------------------------------------------------------------
Phone: (816) 926-4415
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Patrick Van Oostveldt |
Re: First commercial single point confocal
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Search the CONFOCAL archive at
http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal Dear, As far as my memory is correct we recieved the first commercial MRC500 confocal in Europe. Feb 1988. At that time some prototypes of Leica were also displayed in EMBL. The EMBL system even had no possibility to use conventional object observation and hence you needed a rather blind imaging. Quite difficult if you have to look and search your object with alone confocal illumination and slowscanning. Andrew Dixon, was than the most important person at BIORAD, probably he has some exact dates. As they told me the MRC500 was presented to the public in dec 1987 at the american cell biology meeting. Am I correct? Patrick Quoting "Wiegraebe, Winfried" <[hidden email]>: > Search the CONFOCAL archive at > http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal > > How do the Zeiss laser scanning and confocal microscopes fit into this > history? > According to their web-page they had 1982 the first commercial laser > scanning microscope (not confocal), the LSM 44 and 1988 a confocal > system (the LSM 10). > Winfried > > ------------------------------------------------------------------------ > -- > Winfried Wiegraebe, Ph.D. > Dir. of Advanced Instrumentation & Physics > Stowers Institute for Medical Research > 1000 E. 50th St, Rm 454b > Kansas City, MO 64110 > USA > > Phone: (816) 926-4415 > Cell: (816) 824-0287 > Fax: (816) 926-2088 > Email: [hidden email] > Web: www.stowers-institute.org > http://research.stowers-institute.org/wiw/ > > > -- Dep. Moleculaire Biotechnologie Coupure links 653 B 9000 GENT tel 09 264 5969 fax 09 264 6219 |
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James Pawley |
Re: First commercial single point confocal
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In reply to this post by Michael Cammer
Search the CONFOCAL archive at
http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal >Search the CONFOCAL archive at >http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal > >What was the vintage of the Sarastro(sp?)? Or is this the SOM 100. At >least now I have an idea where the name of the SOM software we used on the >BioRad came from. Thanks! >-mc Sarastro, later sold to Molecular Dynamics, was also very early and might have sold in Sweden before the SOM-100. The patent was filed in Canada 3/5/1985 and in US 2/212/1985. Sweden was presumably earlier. The person who would know in Kjell Carlsson who designed it but is no longer in the field. Jim P. > > Search the CONFOCAL archive at >> http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal >> >> I'm sure you are right about the Bio-Rad in >> principle, but it wasn't the well-known MRC >> 500, but the very different SOM 100. In fact >> so far as I can find out the first microscope >> advertised for sale was by Oxford Optoelectronics >> but I believe that before the first one was >> delivered the design had been taken over by a company >> called Dubilier, who were thus the first to actually >> sell one. Dubilier was then bought by Polaron >> who in turn were taken over by Bio-Rad. >> >> The SOM 100 was a stage-scanning machine using a >> He-Ne laser and was intended for reflection imaging, >> so it found little use in biology. Bio-Rad soon >> dumped it in favour of Brad Amos' MRC design, which >> had biological imaging as its first priority. This >> caused some grief to the Oxford team who had developed >> the SOM - and just to rub salt into the wound it was >> a design from Cambridge which supplanted it! >> >> Guy >> >> Optical Imaging Techniques in Cell Biology >> by Guy Cox CRC Press / Taylor & Francis >> http://www.guycox.com/optical.htm >> ______________________________________________ >> Associate Professor Guy Cox, MA, DPhil(Oxon) >> Electron Microscope Unit, Madsen Building F09, >> University of Sydney, NSW 2006 >> ______________________________________________ >> Phone +61 2 9351 3176 Fax +61 2 9351 7682 >> Mobile 0413 281 861 >> ______________________________________________ >> http://www.guycox.net >> -----Original Message----- >> From: Confocal Microscopy List [mailto:[hidden email]] On >> Behalf Of Boris Zarda >> Sent: Monday, 5 November 2007 8:03 PM >> To: [hidden email] >> Subject: First commercial single point confocal >> >> Search the CONFOCAL archive at >> http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal >> >> Dear all, >> >> one of my customers asked me the question about what was the first >> commercial single point scanner. I was much tempted to answer straight >> away with "Biorad", but the longer I think about it the more I am in >> doubt. At that time I was in my (microscopic) larvae stage and I am not >> sure to have the time scale right. And I would like to give the correct >> answer unbiased by company or geographic issues. >> >> Your input would be much appreciated >> >> Boris >> ___________________________________________________ >> >> Boris Zarda >> Dr. rer. nat. >> Sales Manager Research Switzerland >> >> Leica Microsystems (Schweiz) AG >> Verkaufsgesellschaft >> Max Schmidheiny-Strasse 201 >> CH-9435 Heerbrugg >> Tel +41 44 768 36 30 >> Fax +41 71 726 34 44 >> >> >> >> ______________________________________________________________________ >> This email has been scanned by the MessageLabs Email Security System. >> For more information please visit http://www.messagelabs.com/email >> ______________________________________________________________________ >> >> No virus found in this incoming message. >> Checked by AVG Free Edition. >> Version: 7.5.503 / Virus Database: 269.15.21/1110 - Release Date: >> 4/11/2007 9:37 PM >> >> >> No virus found in this outgoing message. >> Checked by AVG Free Edition. >> Version: 7.5.503 / Virus Database: 269.15.22/1112 - Release Date: >> 5/11/2007 7:11 PM >> >> > > >_________________________________________ >Michael Cammer http://www.aecom.yu.edu/aif/ -- **************************************** Prof. James B. Pawley, Ph. 608-263-3147 Room 223, Zoology Research Building, FAX 608-262-9083 250 N. Mills St., Madison, WI, 53706 [hidden email] "A scientist is not one who can answer questions but one who can question answers." Theodore Schick Jr., Skeptical Enquirer, 21-2:39 |
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Kevin W Eliceiri |
Re: First commercial single point confocal
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In reply to this post by Patrick Van Oostveldt
Search the CONFOCAL archive at
http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal In 2003 Brad Amos and John White wrote a review for the Journal of Biology of the Cell entitled "How the Confocal Laser Scanning Microscope. entered Biological Research" that covers the history of the MRC500 development and timeline of other confocal developments. This is freely available at: www.biolcell.org/boc/095/0335/boc0950335.pdf In this review they state that one of the first public showings of their prototype was at the Symposium of the International Society for Analytical Cytology in Cambridge, UK, in 1987. Kevin W. Eliceiri Director Laboratory for Optical and Computational Instrumentation http://www.loci.wisc.edu Room 271 Animal Sciences 1675 Observatory Drive Madison, WI 53706 Phone: 608-263-6288 Fax: 608-262-4570 ----- Original Message ----- From: Patrick Van Oostveldt <[hidden email]> Date: Wednesday, November 7, 2007 11:50 am Subject: Re: First commercial single point confocal To: [hidden email] > Search the CONFOCAL archive at > http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal > > Dear, > > As far as my memory is correct we recieved the first commercial MRC500 > > confocal in Europe. Feb 1988. At that time some prototypes of Leica > were also displayed in EMBL. The EMBL system even had no possibility > > to use conventional object observation and hence you needed a rather > > blind imaging. Quite difficult if you have to look and search your > object with alone confocal illumination and slowscanning. > Andrew Dixon, was than the most important person at BIORAD, probably > > he has some exact dates. > > As they told me the MRC500 was presented to the public in dec 1987 at > > the american cell biology meeting. > Am I correct? > > Patrick > > Quoting "Wiegraebe, Winfried" <[hidden email]>: > > > Search the CONFOCAL archive at > > http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal > > > > How do the Zeiss laser scanning and confocal microscopes fit into this > > history? > > According to their web-page they had 1982 the first commercial laser > > scanning microscope (not confocal), the LSM 44 and 1988 a confocal > > system (the LSM 10). > > Winfried > > > > ------------------------------------------------------------------------ > > -- > > Winfried Wiegraebe, Ph.D. > > Dir. of Advanced Instrumentation & Physics > > Stowers Institute for Medical Research > > 1000 E. 50th St, Rm 454b > > Kansas City, MO 64110 > > USA > > > > Phone: (816) 926-4415 > > Cell: (816) 824-0287 > > Fax: (816) 926-2088 > > Email: [hidden email] > > Web: www.stowers-institute.org > > http://research.stowers-institute.org/wiw/ > > > > > > > > > > -- > Dep. Moleculaire Biotechnologie > Coupure links 653 > B 9000 GENT > > tel 09 264 5969 > fax 09 264 6219 |
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In reply to this post by Zarda, Boris
Search the CONFOCAL archive at
http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal We had this discussion in this list 9 years ago and I said then that the SOM 100 was on sale a year before the Sarastro Phoibos, and the Oxford Optoelectronics / Dubilier machine was on sale well before that (obviously, since it was the predecessor of the SOM). According to the Encyclopedia of Optical Engineering By Ronald G. Driggers "the first commercial confocal microscope was launched by Oxford Optoelectronics in 1982". This is well before Sarastro had even filed their patents. In an historical review, Biology of the Cell 95, 335-342 (2003) Brad Amos and JG White describe the Kjell Carlsson's Sarastro Phoibos as appearing at the same time as their MRC 500. Guy Optical Imaging Techniques in Cell Biology by Guy Cox CRC Press / Taylor & Francis http://www.guycox.com/optical.htm ______________________________________________ Associate Professor Guy Cox, MA, DPhil(Oxon) Electron Microscope Unit, Madsen Building F09, University of Sydney, NSW 2006 ______________________________________________ Phone +61 2 9351 3176 Fax +61 2 9351 7682 Mobile 0413 281 861 ______________________________________________ http://www.guycox.net -----Original Message----- From: Confocal Microscopy List [mailto:[hidden email]] On Behalf Of James Pawley Sent: Thursday, 8 November 2007 12:00 PM To: [hidden email] Subject: Re: First commercial single point confocal Search the CONFOCAL archive at http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal >Search the CONFOCAL archive at >http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal > >What was the vintage of the Sarastro(sp?)? Or is this the SOM 100. At >least now I have an idea where the name of the SOM software we used on >the BioRad came from. Thanks! >-mc Sarastro, later sold to Molecular Dynamics, was also very early and might have sold in Sweden before the SOM-100. The patent was filed in Canada 3/5/1985 and in US 2/212/1985. Sweden was presumably earlier. The person who would know in Kjell Carlsson who designed it but is no longer in the field. Jim P. > > Search the CONFOCAL archive at >> http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal >> >> I'm sure you are right about the Bio-Rad in principle, but it >> wasn't the well-known MRC 500, but the very different SOM 100. In >> fact so far as I can find out the first microscope advertised for >> sale was by Oxford Optoelectronics but I believe that before the >> first one was delivered the design had been taken over by a company >> called Dubilier, who were thus the first to actually sell one. >> Dubilier was then bought by Polaron who in turn were taken over by >> Bio-Rad. >> >> The SOM 100 was a stage-scanning machine using a He-Ne laser and >> was intended for reflection imaging, so it found little use in >> biology. Bio-Rad soon dumped it in favour of Brad Amos' MRC design, >> which had biological imaging as its first priority. This caused >> some grief to the Oxford team who had developed the SOM - and just >> to rub salt into the wound it was a design from Cambridge which >> supplanted it! >> >> Guy >> >> Optical Imaging Techniques in Cell Biology >> by Guy Cox CRC Press / Taylor & Francis >> http://www.guycox.com/optical.htm >> ______________________________________________ >> Associate Professor Guy Cox, MA, DPhil(Oxon) Electron Microscope >> Unit, Madsen Building F09, University of Sydney, NSW 2006 >> ______________________________________________ >> Phone +61 2 9351 3176 Fax +61 2 9351 7682 >> Mobile 0413 281 861 >> ______________________________________________ >> http://www.guycox.net >> -----Original Message----- >> From: Confocal Microscopy List >> [mailto:[hidden email]] On Behalf Of Boris Zarda >> Sent: Monday, 5 November 2007 8:03 PM >> To: [hidden email] >> Subject: First commercial single point confocal >> >> Search the CONFOCAL archive at >> http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal >> >> Dear all, >> >> one of my customers asked me the question about what was the first >> commercial single point scanner. I was much tempted to answer >> straight away with "Biorad", but the longer I think about it the >> more I am in doubt. At that time I was in my (microscopic) larvae >> stage and I am not sure to have the time scale right. And I would >> like to give the correct answer unbiased by company or geographic issues. >> >> Your input would be much appreciated >> >> Boris >> ___________________________________________________ >> >> Boris Zarda >> Dr. rer. nat. >> Sales Manager Research Switzerland >> >> Leica Microsystems (Schweiz) AG >> Verkaufsgesellschaft >> Max Schmidheiny-Strasse 201 >> CH-9435 Heerbrugg >> Tel +41 44 768 36 30 >> Fax +41 71 726 34 44 >> >> >> >> >> _____________________________________________________________________ >> _ This email has been scanned by the MessageLabs Email Security >> System. >> For more information please visit http://www.messagelabs.com/email >> _____________________________________________________________________ >> _ >> >> No virus found in this incoming message. >> Checked by AVG Free Edition. >> Version: 7.5.503 / Virus Database: 269.15.21/1110 - Release Date: >> 4/11/2007 9:37 PM >> >> >> No virus found in this outgoing message. >> Checked by AVG Free Edition. >> Version: 7.5.503 / Virus Database: 269.15.22/1112 - Release Date: >> 5/11/2007 7:11 PM >> >> > > >_________________________________________ >Michael Cammer http://www.aecom.yu.edu/aif/ -- **************************************** Prof. James B. Pawley, Ph. 608-263-3147 Room 223, Zoology Research Building, FAX 608-262-9083 250 N. Mills St., Madison, WI, 53706 [hidden email] "A scientist is not one who can answer questions but one who can question answers." Theodore Schick Jr., Skeptical Enquirer, 21-2:39 No virus found in this incoming message. Checked by AVG Free Edition. Version: 7.5.503 / Virus Database: 269.15.24/1117 - Release Date: 7/11/2007 10:52 PM No virus found in this outgoing message. Checked by AVG Free Edition. Version: 7.5.503 / Virus Database: 269.15.24/1117 - Release Date: 7/11/2007 10:52 PM |
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Shalin Mehta |
Re: First commercial single point confocal
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Search the CONFOCAL archive at
http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal
Dear All,
I got to know some more history from Colin (who was instrumental in establishing Oxford optoelectronics). It turns out that the first commercial point scanning confocal was prototyped ca. 1975 in Oxford which eventually became SOM-25. SOM-100 was preceded by SOM-25. They sold couple of them to semiconductor developers (texas instruments and perhaps intel) that were interested in studying surface defects. On the list there was discussion about origin of the term 'confocal' sometime back. These interesting chronological details transpired during our discussion... 1940: Goldman used slit to obtain 'sections' in opthalmic scope... It also employed idea of illuminationg and detecting the signal at different angles (termed angular gating) to get rid of stray light (a la dark-field ?!) (Goldman H., Spaltlampenphotographie undphotometrie. Opthalmologica 98, 257-270) 1943: Z Koana from University of Tokyo publishes (in Japanese) idea of point illumination and point detection using lamp+pin-hole and photodetector+pin-hole. Pin-holes were meant to get rid of stray light during spectrophotometry. 1955: Hiroto Naora (Koana's junior collegue) publishes results based on this method...(H. Naora, Microspectrophotometry of cell nucleus stained by Feulgen reaction I. Microspectrophotometric apparatus without Schwarzschild-Villiger effect, <a href="javascript:AL_get(this, 'jour', 'Exp Cell Res.');">Exp Cell Res. 1955 Apr;8(2):259-78.) The S-V effect dealt with in this paper is stray reflections. Fig.3 of this paper (at http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WFC-4DYV56H-26&_user=10&_coverDate=12%2F31%2F1955&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=72a34fa8ece505094e6000c56a87de82 ) shows the apparatus. 1957: Marvin Minsky's patent (Very similar to Koana-Naora instrument in terms of point illumination and point detection) 1975: Oxford optoelectronics established 1977: First use of term 'confocal' in journal article...CJR Sheppard, A Choudhury, Optica Acta, 24, 1051-1073 (1977)..which as Guy had pointed out earlier was earlier called Type-2 scanning optical microscope.. The excerpt from abstract: "It has been shown that there are two geometries of the [scanning optical] microscope, which have been designated Type 1 and Type 2. ... those of Type 2 (confocal microscopes) ... " Cheers shalin On Nov 8, 2007 12:35 PM, Guy Cox <
[hidden email]> wrote: We had this discussion in this list 9 years ago and I said -- My co-ordinates: Shalin Mehta, Graduate student Graduate Programme in Bioengineering, NUS, Singapore Mobile: +65 90694182 |
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In reply to this post by Zarda, Boris
Search the CONFOCAL archive at
http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal
A couple of footnotes to Shalin's
timeline:
Nobody really seemed to know what had happened to Hiroto
Naora
since that pioneering work - and then we discovered that he
was
working (at an age when most of us would be retired) at the
Australian National University in Canberra. So he
gave an
invited talk on his work at the 2000 Australian
Microscopy
conference in Canberra. It was absolutely fascinating
and one
can only wonder at the difficulties he must have faced
doing
such work in immediately post-war Japan. Colin and I
talked to
him afterwards and he was very definite that it was his
research,
and Koana was just his supervisor.
I have a micrograph I use in my lectures which shows the
Schwarzschild-
Villiger effect rather well - in a bright-field
fluorescence image of a leaf
you can also see the (non-fluorescent) cell walls by the
light they scatter
from the fluorescent chloroplasts - in the confocal they
are (of course)
not seen. People often forget that this is an
additional benefit of confocal
imaging.
Some years back I was involved in a lengthy email exchange
with Marvin
Minsky on historical aspects of confocal, in particular
patent issues. Then
I asked him if he was aware of Naora's work (which was,
after all, published
in leading US journals). I never heard another word
from Marvin.
Guy
Optical Imaging Techniques in Cell Biology From: Confocal Microscopy List [mailto:[hidden email]] On Behalf Of Shalin Mehta Sent: Thursday, 8 November 2007 4:16 PM To: [hidden email] Subject: Re: First commercial single point confocal I got to know some more history from Colin (who was instrumental in establishing Oxford optoelectronics). It turns out that the first commercial point scanning confocal was prototyped ca. 1975 in Oxford which eventually became SOM-25. SOM-100 was preceded by SOM-25. They sold couple of them to semiconductor developers (texas instruments and perhaps intel) that were interested in studying surface defects. On the list there was discussion about origin of the term 'confocal' sometime back. These interesting chronological details transpired during our discussion... 1940: Goldman used slit to obtain 'sections' in opthalmic scope... It also employed idea of illuminationg and detecting the signal at different angles (termed angular gating) to get rid of stray light (a la dark-field ?!) (Goldman H., Spaltlampenphotographie undphotometrie. Opthalmologica 98, 257-270) 1943: Z Koana from University of Tokyo publishes (in Japanese) idea of point illumination and point detection using lamp+pin-hole and photodetector+pin-hole. Pin-holes were meant to get rid of stray light during spectrophotometry. 1955: Hiroto Naora (Koana's junior collegue) publishes results based on this method...(H. Naora, Microspectrophotometry of cell nucleus stained by Feulgen reaction I. Microspectrophotometric apparatus without Schwarzschild-Villiger effect, <A href="javascript:AL_get(this, 'jour', 'Exp Cell Res.');">Exp Cell Res. 1955 Apr;8(2):259-78.) The S-V effect dealt with in this paper is stray reflections. Fig.3 of this paper (at http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WFC-4DYV56H-26&_user=10&_coverDate=12%2F31%2F1955&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=72a34fa8ece505094e6000c56a87de82 ) shows the apparatus. 1957: Marvin Minsky's patent (Very similar to Koana-Naora instrument in terms of point illumination and point detection) 1975: Oxford optoelectronics established 1977: First use of term 'confocal' in journal article...CJR Sheppard, A Choudhury, Optica Acta, 24, 1051-1073 (1977)..which as Guy had pointed out earlier was earlier called Type-2 scanning optical microscope.. The excerpt from abstract: "It has been shown that there are two geometries of the [scanning optical] microscope, which have been designated Type 1 and Type 2. ... those of Type 2 (confocal microscopes) ... " Cheers shalin On Nov 8, 2007 12:35 PM, Guy Cox < [hidden email]> wrote: We had this discussion in this list 9 years ago and I said -- My co-ordinates: Shalin Mehta, Graduate student Graduate Programme in Bioengineering, NUS, Singapore Mobile: +65 90694182 No virus found in this incoming message. No virus found in this outgoing message. |
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In reply to this post by Zarda, Boris
Search the CONFOCAL archive at
http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal
Quite correct. But their LSM44 was not the first
non-confocal scanning
optical microscope. That goes back much earlier to
1950 (prototype)
and 1953 (commercial). Nevertheless it was obviously
a very useful
background for Zeiss to develop their first confocal.
However the LSM10
was not very good. The hardware was basic but
functional but the software
was primitive beyond belief. Given that the MRC500
had really good
hardware and software (within what was possible in
1897) Zeiss had to
move fast to get into the market - and of course they
did just that.
Guy
Optical Imaging Techniques in Cell Biology From: Confocal Microscopy List [mailto:[hidden email]] On Behalf Of Wiegraebe, Winfried Sent: Thursday, 8 November 2007 3:38 AM To: [hidden email] Subject: Re: First commercial single point confocal How do the Zeiss laser scanning and confocal
microscopes fit into this history? Winfried --------------------------------------------------------------------------
Phone: (816) 926-4415 No virus found in this incoming message. No virus found in this outgoing message. |
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Ian Dobbie-2 |
Re: First commercial single point confocal
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Search the CONFOCAL archive at
http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal Guy Cox <[hidden email]> writes: > Search the CONFOCAL archive at http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1= > confocal > was primitive beyond belief. Given that the MRC500 had really good > hardware and software (within what was possible in 1897) Zeiss had to ^^^^ Wow BioRad go back a lot further than I thought! ;-) Ian |
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Shalin Mehta |
Re: First commercial single point confocal
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In reply to this post by Guy Cox
Search the CONFOCAL archive at
http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal
Hi Everyone,
I didn't get it all right...Here are further notes by Colin --------------------------------------------------------------------------------------------- Dear Shalin, almost correct! Actually wedeveloped the Oxford confocal in 1975 but Oxford Opto wasn't started till 1982, with SOM25. In 1984 rights were assigned to Dubilier. They introduced the name Lasersharp. In 1986 rights were transferred to BioRad, who bought the Lasersharp factory in Abingdon. Polaron was a subsidiary of BioRad in UK. With regard to papers on confocal fluorescence there was Ingemar Cox, JMicrosc 1983? Then Brakenhoff and van Resandt. Latter started Heidelberg instruments who also launched early confocal 1985? This was later taken over by Leica. Another paper was Carlsson optics letters 1985? Colin On Nov 8, 2007 4:26 PM, Guy Cox <[hidden email]> wrote:
-- My co-ordinates: Shalin Mehta, Graduate student Graduate Programme in Bioengineering, NUS, Singapore Mobile: +65 90694182 |
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Eric Scarfone |
Re: First commercial single point confocal
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In reply to this post by Kevin W Eliceiri
Search the CONFOCAL archive at
http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal Dear all, It would be really nice to have the whole inside story straightened up someday! A clear distinction should be made also between stage-scanning and beam-scanning. In this respect which was the fisrt beam-scanner? Concerning Sarastro, since I am now located in Sweden I contacted Kjell Carlsson couldn't recall. Niels Alsund, then president of Sarastro, says that the commercial company was founded in 1986 and sold its first set up the same year here at the Karolinska Institutet. The prototype however was running before that (probably at KTH where Kjell worked?) but I got no dates on that! Best Whishes to all. Eric Eric Scarfone, PhD, CNRS, Center for Hearing and communication Research Department of Clinical Neuroscience Karolinska Institutet Postal Address: CFH, M1:02 Karolinska Hospital, SE-171 76 Stockholm, Sweden Work: +46 (0)8-517 70343, Cell: +46 (0)70 888 2352 Fax: +46 (0)8-301876 email: [hidden email] http://www.ki.se/cfh/ ----- Original Message ----- From: Kevin W Eliceiri <[hidden email]> Date: Thursday, November 8, 2007 4:17 am Subject: Re: First commercial single point confocal To: [hidden email] > Search the CONFOCAL archive at > http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal > > In 2003 Brad Amos and John White wrote a review for the Journal of > Biology of the Cell entitled "How the Confocal Laser Scanning > Microscope. entered Biological Research" that covers the history of > the MRC500 development and timeline of other confocal developments. > This is freely available at: > > www.biolcell.org/boc/095/0335/boc0950335.pdf > > In this review they state that one of the first public showings of > their prototype was at > the Symposium of the International Society for Analytical Cytology > in Cambridge, UK, in 1987. > > > Kevin W. Eliceiri > Director > Laboratory for Optical and Computational Instrumentation > http://www.loci.wisc.edu > Room 271 Animal Sciences > 1675 Observatory Drive > Madison, WI 53706 > Phone: 608-263-6288 > Fax: 608-262-4570 > > ----- Original Message ----- > From: Patrick Van Oostveldt <[hidden email]> > Date: Wednesday, November 7, 2007 11:50 am > Subject: Re: First commercial single point confocal > To: [hidden email] > > > Search the CONFOCAL archive at > > http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal > > > > Dear, > > > > As far as my memory is correct we recieved the first commercial > MRC500 > > > > confocal in Europe. Feb 1988. At that time some prototypes of > Leica > > were also displayed in EMBL. The EMBL system even had no > possibility > > > > to use conventional object observation and hence you needed a > rather > > > > blind imaging. Quite difficult if you have to look and search > your > > object with alone confocal illumination and slowscanning. > > Andrew Dixon, was than the most important person at BIORAD, > probably > > > > he has some exact dates. > > > > As they told me the MRC500 was presented to the public in dec > 1987 at > > > > the american cell biology meeting. > > Am I correct? > > > > Patrick > > > > Quoting "Wiegraebe, Winfried" <[hidden email]>: > > > > > Search the CONFOCAL archive at > > > http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal > > > > > > How do the Zeiss laser scanning and confocal microscopes fit > into this > > > history? > > > According to their web-page they had 1982 the first commercial > laser> > scanning microscope (not confocal), the LSM 44 and 1988 a > confocal> > system (the LSM 10). > > > Winfried > > > > > > ---------------------------------------------------------------- > -------- > > > -- > > > Winfried Wiegraebe, Ph.D. > > > Dir. of Advanced Instrumentation & Physics > > > Stowers Institute for Medical Research > > > 1000 E. 50th St, Rm 454b > > > Kansas City, MO 64110 > > > USA > > > > > > Phone: (816) 926-4415 > > > Cell: (816) 824-0287 > > > Fax: (816) 926-2088 > > > Email: [hidden email] > > > Web: www.stowers-institute.org > > > http://research.stowers-institute.org/wiw/ > > > > > > > > > > > > > > > > > -- > > Dep. Moleculaire Biotechnologie > > Coupure links 653 > > B 9000 GENT > > > > tel 09 264 5969 > > fax 09 264 6219 > |
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